Comparison of in-house HIV-1 genotypic drug resistant test with commercial HIV-1 genotypic test kit
نویسندگان
چکیده
منابع مشابه
Predictive value of HIV-1 genotypic resistance test interpretation algorithms.
BACKGROUND Interpreting human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance test results is challenging for clinicians treating HIV-1-infected patients. Multiple drug-resistance interpretation algorithms have been developed, but their predictive value has rarely been evaluated using contemporary clinical data sets. METHODS We examined the predictive value of 4 algorithms at ...
متن کاملWeb resources for HIV type 1 genotypic-resistance test interpretation.
Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1-infected patients. There are many drug-resistance mutations, and they arise in complex patterns that cause varying levels of drug resistance. In addition, HIV-1 exists in vivo as a virus population containing many ge...
متن کاملComparison of HIV-1 Genotypic Resistance Test Interpretation Systems in Predicting Virological Outcomes Over Time
BACKGROUND Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. METHODOLOGY/PRINCIPAL FINDINGS Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was avail...
متن کاملMining complex genotypic features for predicting HIV-1 drug resistance
MOTIVATION Human immunodeficiency virus type 1 (HIV-1) evolves in human body, and its exposure to a drug often causes mutations that enhance the resistance against the drug. To design an effective pharmacotherapy for an individual patient, it is important to accurately predict the drug resistance based on genotype data. Notably, the resistance is not just the simple sum of the effects of all mu...
متن کاملHIV-1 genotypic drug resistance interpretation rules - 2009 Spanish guidelines.
Interpreting the results of drug resistance tests for HIV-1 is one of the most difficult tasks for both clinicians and virologists. There are many amino acid changes in viral proteins influencing the susceptibility to specific drugs, causing loss of activity or conversely hypersusceptibility. Moreover, the results of interactions derived from complex mutational patterns are difficult to predict...
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ژورنال
عنوان ژورنال: Asian Biomedicine
سال: 2011
ISSN: 1875-855X
DOI: 10.5372/1905-7415.0502.032